Scoparone → Schizophrenia

Original Indication

Nutraceutical (coumarin derivative)

Proposed New Indication

Scoparone, un nutraceutique, ameliore les comportements de type schizophrenie induits par le MK-801 chez la souris en activant la voie SIRT1/PGC-1alpha/TFAM, regulant ainsi l'homeostasie mitochondriale et ameliorant la mitophagie.

Proposed Mechanism

Targets: SIRT1, PGC-1alpha, TFAM, Drp1, MFN2, OPA1

Activation de la voie SIRT1/PGC-1alpha/TFAM, regulation de l'homeostasie mitochondriale, inhibition de Drp1, augmentation de MFN2 et OPA1, induction de la mitophagie.

Evidence

Level: In vivo (modele murin)

Source: Repositioning of a nutraceutical, scoparone, in the management of MK-801-induced schizophrenia-like behavior in Mice: An insight into SIRT1/PGC-1alpha/TFAM pathway." (European Journal of Pharmacology, 2025)

Reference: PubMed 40712878

Repurposing Score